Use of an ABC transporter peptide inhibitor
AssigneeHunan University of Science and Engineering
InventorsXiaofang Luo, Zuodong Qin, Meifeng Wang, Dongfang Tang
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Abstract
Disclosed herein is a use of an adenosine triphosphate (ATP) binding cassette (ABC) transporter peptide inhibitor HX-12C. This disclosure also discloses a method of treating a tumor with multidrug resistance mediated by the ABC transporter using a combination of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug. Moreover, this disclosure also provides a composition for treating a tumor with multidrug resistance mediated by an ABC transporter, consisting of the peptide HX-12C shown in SEQ ID NO: 1 and an ABC transporter substrate chemotherapeutic drug.
Claims5
A method of treating a tumor with multidrug resistance mediated by an ABC transporter in a subject in need thereof, comprising:
- administering a combination of 3 μM of a peptide HX-12C shown in SEQ ID NO:
- 1 and an ABC transporter substrate chemotherapeutic drug to the subject;
- wherein the ABC transporter is ABCC1.
A pharmaceutical composition for treating a tumor with multidrug resistance mediated by an ABC transporter, consisting of:
- 3 μM of a peptide HX-12C shown in SEQ ID NO:
- 1;
- and
- an ABC transporter substrate chemotherapeutic drug;
- wherein the ABC transporter is ABCC1, and the ABC transporter substrate chemotherapeutic drug is selected from the group consisting of a vinca alkaloid, an anthracycline, an epipodophyllotoxin and tyrosine kinase inhibitor.
Dependencies are inferred from the claim text.