Agents targeting inhibitor of apoptosis proteins

A compound, or a pharmaceutical salt thereof, or a prodrug thereof, having the formula:

• wherein,
• R1 is —CX13, —CFHX12, —CH2X1, substituted or unsubstituted C1-C4 alkyl;
• L2 is a bond, —NH—, —O—, —S—, —C(O)—, —C(O)NH—, —NHC(O)—, —NHC(O)NH—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R2 is independently cycloalkyl, aryl, or heteroaryl, wherein any cycloalkyl, aryl, or heteroaryl of R2 is optionally substituted with one or more R7 groups;
• L3 is a bond, —NH—, —O—, —S—, —C(O)—, —C(O)NH—, —NHC(O)—, —NHC(O)NH—, —C(O)O—, —OC(O)—, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, substituted or unsubstituted heteroarylene, substituted or unsubstituted alkylarylene, substituted or unsubstituted alkylheteroarylene;
• Ring A is a cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
• R3 is independently halogen, —CX33, —CHX32, —CH2X3, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX33, —OCX32, —OCH2X3, —SO2X3, —SO2C═CH2, —NHSO2CH═CH2, —OSO2X3, —NHSO2X3, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• two adjacent R3 substituents may optionally be joined to form a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• wherein -(Ring A)-(R3)z3 is
• R4 is independently hydrogen, halogen, —CX43, —CHX42, —CH2X4, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX43, —OCHX42, —OCH2X4, —NHC(NH)NH2, —SO2X4, —SO2CH═CH2, —NHSO2CH═CH2, —OSO2X4, —NHSO2X4, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is independently hydrogen, halogen, —CX53, —CHX52, —CH2X5, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHNH2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX53, —OCHX52, —OCH2X5, —NHC(NH)NH2, —SO2X5, —SO2CH═CH2, —NHSO2CH═CH, —OSO2X5, —NHSO2X5, —B(OH)2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• L6 is a bond or unsubstituted methylene;
• R6 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or un substituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R7 is independently halogen, —CX73, —CHX72, —CH2X7, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHN H2, —NH C(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX73, —OCHX72, —OCH2X7, —NHC(NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2Cl, —B(OH)2, —SO2X7, —OSO2X7, —NHSO2X7, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein any alkyl, heteroalkyl, cycloalkyl, heterocyloalkyl, aryl, or heteroaryl of R7 is optionally substituted with one or more R8 groups;
• R8 is independently halogen, —CX83, —CHX82, —CH2X8, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHN H2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX83, —OCHX82, —OCH2X8, —NHC(NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2Cl, —B(OH)2, —SO2X8, —OSO2X8, —NHSO2X8, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein any alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl of R8 is optionally substituted with one or more R8 groups;
• R9 is independently halogen, —CX93, —CHX92, —CH2X9, —CN, —OH, —NH2, —COH, —COOH, —CONH2, —NO2, —SH, —SO3H, —SO4H, —SO2NH2, —NHNH2, —ONH2, —NHC(O)NHN H2, —NHC(O)NH2, —NHSO2H, —NHC(O)H, —NHC(O)OH, —NHOH, —OCX93, —OCHX92, —OCH2X9, —NHC(NH)NH2, —N═C(NH2)2, —CH2SO3−, —PO3−2, —SO3−, —SO2NH2, —CH2PO3−2, —CH2SO2NH2, —NHC(O)CHCH2, —NHC(O)CH2Cl, —B(OH)2, —SO2X9, —OSO2X9, —NHSO2X9, —SO2CH═CH2, —NHSO2CH═CH2, —CO-oxiranyl, —CO-aziridinyl, epoxidinyl, oxaziridinyl, aziridinyl, —OCH2C≡CH, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;
• each X1, X2, X3, X4, X5, X7, X8, and X9 is independently —F, —Cl, —Br, or —I;
• and
• z3 is independently an integer from 0 to 3.