Oncolytic rhabdovirus expressing IL12
AssigneeTurnstone Limited Partnership
InventorsAlmohanad Alkayyal, Rebecca Auer, John Cameron Bell
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Abstract
Disclosed herein is an oncolytic recombinant Maraba virus whose genome comprises one or more nucleic acid sequences that, in combination, encode an interleukin-12 (IL12) protein or a functional portion thereof. A method for treating a cancer in a patient using the oncolytic recombinant Maraba virus is also disclosed. The present disclosure also provides a tumour cell infected with an oncolytic rhabdovirus whose genome comprises one or more nucleic acid sequences that, in combination, encode an interleukin-12 (IL12) protein or a functional portion thereof, for use as an infected cell vaccine (ICV) for the treatment of a cancer. A method for treating a cancer in a patient using the infected cell vaccine is also disclosed.
Claims34
An oncolytic Maraba virus comprising a genome that comprises, from 3′ end to 5′ end, nucleic acid sequences encoding an N, a P, an M, a G, and an L protein, and one or more nucleic acid sequences that, alone or in combination, are capable of expressing a human interleukin-12 (IL12) protein or a functional portion thereof, wherein the one or more nucleic acid sequences that, alone or in combination, are capable of expressing a human IL12 protein is/are located in the genome between the 3′ end and the nucleic acid sequences encoding the N, P, M, G, and L proteins, in between the nucleic acid sequences encoding the N and the P proteins, in between the nucleic acid sequences encoding the P and the M proteins, in between the nucleic acid sequences encoding the M and the G, or between the '5 end and the nucleic acid sequences encoding the N, P, M, G and L proteins.
Dependencies are inferred from the claim text.