Methods and compositions to modulate antibiotic resistance and gastrointestinal microbiota
AssigneeOhio State Innovation Foundation
InventorsHua Wang, Lu Zhang, Yang Zhou, Zihua Wang
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Abstract
Disclosed herein are methods and compositions related to probiotic formulas. These formulas comprise the bacterial strain Lactobacillus crispatus WZ-12 or a derivative thereof. Other strains which can be included in the composition include, but are not limited to, Lactobacillus salivarius 1-14, or Lactobacillus reuteri 2-2, and derivatives thereof. These compositions can be used in a variety of methods to treat and/or ameliorate diseases, such as colonization of antibiotic-resistant bacteria in the host organism. Also disclosed herein are methods of treating those subjects in need thereof by administering the compositions disclosed herein.
Claims9
A feed composition comprising a probiotic treatment, wherein said probiotic treatment comprises Lactobacillus crispatus WZ-12 or a derivative thereof, wherein said Lactobacillus crispatus WZ-12 derivative improves one or more probiotic qualities in a subject compared to a parental Lactobacillus crispatus WZ-12 strain;
- and an ingestible food product;
- wherein the probiotic treatment reduces antibiotic resistant Escherichia coli in a gut microbiota of the subject.
A feed composition comprising Lactobacillus crispatus WZ-12 or a derivative thereof and E. coli strain M9-4-1 or a derivative thereof and an ingestible food product;
- wherein the composition comprises Lactobacillus crispatus WZ-12 or a derivative thereof and E. coli strain M9-4-1 or a derivative thereof in an amount sufficient for use as a probiotic treatment of a subject, wherein the probiotic treatment reduces antibiotic resistant Escherichia coli in a gut microbiota of the subject.
Dependencies are inferred from the claim text.