Formulations of calcium and phosphate for oral inflammation
AssigneeBausch Health Companies Inc.
InventorsBartholomew Weldon, Edward Kobus, Sandryne Dumoulin, Aimesther Betancourt, Patrick Gosselin
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Abstract
The present invention generally relates to liquid compositions and methods for treating oral inflammation by administering a liquid composition to the oral cavity. The liquid composition is prepared from a powder containing calcium glycerophosphate, one or more sodium phosphate salts, sodium chloride, and optionally sodium bicarbonate and silica. The powder is mixed with a quality of water to form a liquid that is supersaturated with calcium ions and phosphate ions and is essentially free of visible particles and precipitate.
Claims10
A liquid composition supersaturated in calcium ions and phosphate ions, the liquid composition being a product of mixing a powder with water in a weight ratio of powder-to-water from about 0.005:1 to about 0.1:1, and wherein the powder comprises:
- (i) calcium glycerophosphate in an amount of from about 5% w/w to 25% w/w of the powder;
- (ii) dibasic sodium phosphate anhydrous in an amount of from about 0.5% w/w to about 10% w/w of the powder;
- (iii) monobasic sodium phosphate anhydrous in an amount of from about 0.3% w/w to about 6% w/w of the powder, and (iv) sodium chloride;
- and wherein the liquid composition has a pH of from about 6.5 to about 7.5 and is free of visible particles and precipitates.
Dependencies are inferred from the claim text.