Biodegradable, antioxidant, thermally responsive injectable hydrogel and uses therefor
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsWilliam R. Wagner, Yasumoto Matsumura, Murugesan Velayutham, Yang Zhu
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Abstract
Provided herein are antioxidant, thermally-responsive copolymer-based compositions and methods of making and using the compositions, e.g., for treatment of ischemia reperfusion injury in a patient. The copolymer comprises a hydrocarbyl backbone, and a plurality of pendant pyrrolidone, antioxidant radical, polyester oligomer, and N-alkyl amide groups.
Claims3
A thermal responsive, biodegradable copolymer composition, comprising n-isopropylacrylamide (NIPAAm) residues, vinyl pyrrolidone residues, methacrylate-polylactide (MAPLA) residues, and methacrylate-TEMPO (MATEMPO), the (MATEMPO) bound to one or more of the MAPLA residues through an amide bond, the copolymer having a transition temperature between 10° C. and 35° C., or between 15° C. and 30° C., above which temperature, the polymer composition transitions from an aqueous-miscible state to a hydrogel having a higher viscosity, partially-miscible or immiscible state in an aqueous solution.
Dependencies are inferred from the claim text.