Treatment of hearing loss
AssigneeMassachusetts Eye and Ear Infirmary
InventorsZheng-Yi Chen, Wenyan Li, Yi-Zhou Quan
Life of this patent
Estimating the term…
Abstract
Compositions for regeneration of inner cells and for treating hearing loss comprise at least one modulator of mechanistic target of rapamycin (mTOR) sufficient to induce reprogramming proliferation and regeneration of inner ear cells. The composition include, in some instances, an effective amount of one or more phosphatase and tensin homolog (PTEN) inhibitors, MYC/NOTCH modulators, Atonal Homolog 1 (Atoh1) modulators or combinations thereof.
Claims7
A method of regenerating inner ear cells in mature mammalian cochlea in a subject in need thereof, comprising contacting the cochlea with an effective amount of sodium valproate (VPA) and at least one activator of mechanistic target of rapamycin (mTOR), selected from the group consisting of MHY1485, 3-benzyl-5-((2-nitrophenoxy) methyl)dihydrofuran-2(3H)-one (3BDO), salidroside, and polynucleotides encoding mTOR, sufficient to induce reprogramming, proliferation and regeneration of inner ear cells;
- thereby regenerating the inner ear cells in mature mammalian cochlea.
A composition comprising:
- an effective amount of sodium valproate (VPA) and at least one activator of mechanistic target of rapamycin (mTOR), selected from the group consisting of MHY1485, 3-benzyl-5-((2-nitrophenoxy) methyl)dihydrofuran-2(3H)-one (3BDO), salidroside, and polynucleotides encoding mTOR.
Dependencies are inferred from the claim text.