Oxazolidinone antibiotic compounds and process of preparation

A compound of Formula I

• or its stereoisomers, pharmaceutically acceptable salts, complexes, hydrates, solvates, tautomers, polymorphs, racemic mixtures, optically active forms and pharmaceutically active derivatives thereof,
• wherein R1 is selected from C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C1-6 alkylamino, C1-6 aminoalkylene, or 4-7 membered saturated or unsaturated carbocyclyl or heterocyclyl ring, wherein the heterocyclyl ring is optionally substituted with up to three heteroatoms independently selected from O, N, or S, wherein C1-6 alkyl, C2-6 alkenyl, C3-6 cycloalkyl, C1-6 alkylamino, C1-6 aminoalkylene, and 4-7 membered saturated or unsaturated carbocyclyl or heterocyclyl ring are optionally substituted with 1 to 3 groups independently selected from halogen, amino, hydroxy, SO3H, O—PO3H2, COOR8, CONHR8, SO2NHR8, methylsulfone, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-6 cycloalkyl, C3-6 cycloalkylamino, C3-6 aminocycloalkyl, C3-6 cycloalkylhydroxy, C1-6 alkylamino, or 3-7 membered saturated or unsaturated heterocyclyl ring optionally substituted with up to three heteroatoms independently selected from O, N, or S;
• R8 is selected from hydrogen, or C1-6 alkyl;
• R2 is selected from hydrogen, halogen, hydroxyl, cyano, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, or C1-6 alkyl;
• R3 is selected from hydrogen, fluoro, C1-4 alkoxy, hydroxyl, or amino;
• X1 is N or CR4;
• R4 is selected from hydrogen, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, or C1-6 alkyl;
• X2 is N or CR5;
• R5 is selected from hydrogen, cyano, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C1-6 haloalkoxy, or COOH, wherein C1-6 alkyl, and C1-6 alkylamino are optionally substituted with one or more groups selected from COOH, hydroxyl, amino, or C1-6 alkyl;
• n1 is 0 or 1;
• n2 is 1 or 2;
• R6 is selected from hydrogen, C1-6 alkoxy, or C1-6 alkyl;
• Y1, and Y2 are independently selected from N or CR7;
• R7 is selected from hydrogen, halogen, cyano, C1-6 alkoxy, C1-6 haloalkyl, C1-6 haloalkoxy, or C1-6 alkyl;
• and
• Z1 is selected from O, S, NH, or CH2.