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US 11,590,133 B2Granted
Methods and compositions for treatment of BRAF mutant cancers
OwnerPiro Litoinventor
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Abstract
The present invention provides various compositions and methods useful for the treatment of BRAF-mutant tumors, such as BRAFV600E-mutant tumors. In some embodiments such methods involve administration of three active agents—a RAF inhibitor, a MEK inhibitor, and an ERK inhibitor. The present invention also provides novel intermittent dosing regimens for these three active agents that maintain maximal anti-tumor efficacy while also minimizing toxicity.
Claims18
A method of treating a BRAFV600E mutant lung tumor or melanoma in a subject in need thereof, the method comprising concurrently administering an effective amount of:
- (a) a RAF inhibitor, (b) a MEK inhibitor, and (c) an ERK inhibitor to a subject having a BRAFV600E mutant lung tumor or melanoma on an intermittent dosing schedule, thereby treating the lung tumor or melanoma in the subject.
Dependencies are inferred from the claim text.