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US 11,590,126 B2Granted
Benzamide compounds
AssigneeRecurium IP Holdings, LLC
InventorsJoseph Robert Pinchman, Peter Qinhua Huang, Kevin Duane Bunker, Rakesh Kumar Sit, Ahmed Abdi Samatar
Life of this patent
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Abstract
Compounds of Formula (I) are provided herein. Such compounds, as well as pharmaceutically acceptable salts and compositions thereof, are useful for treating diseases or conditions, including conditions characterized by excessive cellular proliferation, such as cancer and tumors, as well as viral infections such as HIV.
Claims97
A compound of Formula (I), or a pharmaceutically acceptable salt thereof, having the structure:
- wherein:
- R1 is selected from the group consisting of hydrogen, halogen, a substituted or unsubstituted C1-C6 alkyl, a substituted or unsubstituted C1-C6 haloalkyl, a substituted or unsubstituted C3-C6 cycloalkyl, a substituted or unsubstituted C1-C6 alkoxy, an unsubstituted mono-C1-C6 alkylamine and an unsubstituted di-C1-C6 alkylamine;
- each R2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C1-C6 alkyl, a substituted or unsubstituted C1-C6 haloalkyl and a substituted or unsubstituted C3-C6 cycloalkyl;
- or
- when m is 2 or 3, each R2 is independently selected from the group consisting of halogen, a substituted or unsubstituted C1-C6 alkyl, a substituted or unsubstituted C1-C6 haloalkyl and a substituted or unsubstituted C3-C6 cycloalkyl, or two R2 groups taken together with the atom(s) to which they are attached form a substituted or unsubstituted C3-C6 cycloalkyl or a substituted or unsubstituted 3 to 6 membered heterocyclyl;
- R3 is selected from the group consisting of X—R3A,
- R3A is a substituted or unsubstituted 5 to 10 membered heteroaryl;
- R4 is selected from the group consisting of NO2, S(O)R6, SO2R6, halogen, cyano and an unsubstituted C1-C6 haloalkyl;
- R5 is selected from the group consisting of —X1-(Alk1)n-R7 and —X2(CHR8)-(Alk2)p-X3—R9;
- Alk1 and Alk2 are independently selected from an unsubstituted C1-C4 alkylene and a C1-C4 alkylene substituted with 1, 2 or 3 substituents independently selected from fluoro, chloro, an unsubstituted C1-C3 alkyl and an unsubstituted C1-C3 haloalkyl;
- R6 is selected from the group consisting of a substituted or unsubstituted C1-C6 alkyl, a substituted or unsubstituted C1-C6 haloalkyl and a substituted or unsubstituted C3-C6 cycloalkyl;
- R7 is selected from a substituted or unsubstituted C1-C6 alkoxy, a substituted or unsubstituted C3-C10 cycloalkyl, a substituted or unsubstituted 3 to 10 membered heterocyclyl, hydroxy, amino, a substituted or unsubstituted mono-substituted amine group, a substituted or unsubstituted di-substituted amine group, a substituted or unsubstituted N-carbamyl, a substituted or unsubstituted C-amido and a substituted or unsubstituted N-amido;
- R8 is selected from a substituted or unsubstituted 3 to 10 membered heterocyclyl(C1-C6 alkyl), a substituted or unsubstituted di-C1-C6 alkylamine(C1-C6 alkyl) and a substituted or unsubstituted mono-C1-C6 alkylamine(C1-C6 alkyl);
- R9 is selected from a substituted or unsubstituted 5 to 10 membered heteroaryl and a substituted or unsubstituted C6-C10 aryl;
- m is 0, 1, 2 or 3;
- n and p are independently selected from 0 and 1;
- X1 and X2 are —O—;
- and
- X and X3 are independently selected from the group consisting of —O—, —S— and —NH—.
16 more elements
Dependencies are inferred from the claim text.