Compositions and methods for reactivating latent immunodeficiency virus using a GSK-3 inhibitor

A method of reducing the number of cells containing a latent human immunodeficiency virus in an individual, the method comprising administering to the individual an effective amount of a glycogen synthase kinase 3 inhibitor, wherein the glycogen synthase kinase 3 inhibitor reactivates latent HIV integrated into the genome of one or more cells in the individual, wherein the glycogen synthase kinase 3 inhibitor is Tideglusib (4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione)) or pharmaceutically acceptable salt thereof.

A method of treating a human immunodeficiency virus (HIV) infection in an individual, the method comprising:

• administering to an individual an effective amount of a glycogen synthase kinase 3 inhibitor, wherein the glycogen synthase kinase 3 inhibitor reactivates latent HIV integrated into the genome of a cell in the individual, wherein the glycogen synthase kinase 3 inhibitor is Tideglusib (4-benzyl-2-(naphthalen-1-yl)-1,2,4-thiadiazolidine-3,5-dione)) or pharmaceutically acceptable salt thereof;
• and
• administering to the individual an effective amount of a second active agent, wherein the second active agent inhibits an immunodeficiency virus function selected from viral replication, viral protease activity, viral reverse transcriptase activity, viral entry into a cell, viral integrase activity, viral Rev activity, viral Tat activity, viral Nef activity, viral Vpr activity, viral Vpu activity, and viral Vif activity.