Asenapine-containing adhesive patch
AssigneeHisamitsu Pharmaceutical Co., Inc.
InventorsMasaki Yukuhiro, Yuka Takagi, Yasunari Michinaka
Life of this patent
Estimating the term…
Abstract
An object of the present invention is to provide an asenapine-containing patch having excellent sustained-release properties while enhancing skin permeability by using a silicone-based pressure-sensitive adhesive base. The present invention relates to a patch having a support and a pressure-sensitive adhesive layer, wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base and a release control agent, and the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
Claims8
A patch comprising a support and a pressure-sensitive adhesive layer,
- wherein the pressure-sensitive adhesive layer comprises asenapine and/or a pharmaceutically acceptable salt thereof, a silicone-based pressure-sensitive adhesive base, and a release control agent selected from the group consisting of oleic acid, magnesium aluminometasilicate, methacrylic acid-methacrylate copolymers, N-methyl-2-pyrrolidone, and (meth)acrylate (co)polymers, and
- wherein the ratio of the maximum skin permeation rate of asenapine to the minimum skin permeation rate from the time when the maximum skin permeation rate is reached to 24 hours is less than 1.62.
Dependencies are inferred from the claim text.