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US 11,590,094 B2Granted
Fixed dose combination formulations for treating pain
AssigneeNevakar Injectables Inc.
InventorsVarun Khurana, Tushar Hingorani, Jack Martin Lipman, Kumaresh Soppimath
Life of this patent
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Abstract
Fixed-dose combination drugs comprising an NSAID as a first drug component and a GABA-type calcium channel blocker as a second drug component are contemplated. Further contemplated aspects also include methods of administration of combination drugs and drugs contained herein.
Claims9
A fixed-dose combination drug, comprising:
- an NSAID (non-steroidal anti-inflammatory drug) as a first drug component in a first layer, and a GABA (gamma- aminobutyric acid)-type calcium channel blocker as a second drug component in a second layer;
- wherein the NSAID is acetaminophen and wherein the GABA (gamma-aminobutyric acid)-type calcium channel blocker is pregabalin;
- wherein the fixed-dose combination drug is formulated for oral administration such that a single oral dosage unit contains the first layer coupled and adjacent to the second layer, and wherein the fixed-dose combination drug provides upon oral administration in the single dosage unit to an individual in need thereof the NSAID in a sustained release in which cumulatively between 40-80% of the NSAID are released over a period of six to eight hours, and the GABA-type calcium channel blocker in a sustained release in which cumulatively between 40-80% of the GABA-type calcium channel blocker are released over a period of two hours.
Dependencies are inferred from the claim text.