Acetaminophen formulation with protection against toxic effects of overdose
OwnerKevin M. Strait, Daniel J. Strait +1inventors
InventorsKevin M. Strait, Daniel J. Strait, Cameron D. Kawato
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Abstract
An oral pharmaceutical dosage form that comprises both acetaminophen and a glutathione replenishing agent, such as N-acetylcysteine. This allows co-administering the glutathione replenishing agent along with acetaminophen, which may be beneficial in rapidly counteracting the toxic effects of acetaminophen overdose. The oral dosage form could be in the form of a tablet or capsule. The dosage form may be designed to compartmentally separate the glutathione replenishing agent from having chemical interaction with the acetaminophen. The dosage form may be designed to mask the taste or smell of the glutathione replenishing agent.
Claims12
A pharmaceutical tablet comprising:
- an inner core comprising N-acetylcysteine in an amount of at least 50 mg;
- and
- a shell that surrounds the inner core, the shell comprising acetaminophen in an amount of 100 to 1,500 mg;
- wherein the shell comprises a cup structure surrounding a portion of the inner core and a capping layer over the cup structure, and wherein the acetaminophen is contained in the cup structure, the capping layer, or both;
- and
- wherein the ratio (by weight) of N-acetylcysteine to the acetaminophen is in the range of 1:20 to 1:5.
Dependencies are inferred from the claim text.