Microcapsules for controlled delivery of an active pharmaceutical ingredient
OwnerRoman Bielski, Zbigniew Janusz Witczakinventors
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Abstract
The present invention relates a microcapsule that comprises an active pharmaceutical ingredient and a polymeric shell comprised of polymeric materials such as polyether, polyester, polyamine, polyamide, polyurea, polyurethane, polythiocarbamate, and polythiocarbonate. The outer surface of shell comprises surface functional groups such as hydroxide, primary amine, carboxylic acid, or protected forms thereof. These surface functional groups may be reacted further with reactants to place specific organic groups on the surface of the microcapsule. Such microcapsules are prepared by a modified interfacial condensation polymerization.
Claims20
A microcapsule comprising a core encapsulated by a polymeric shell, wherein
- the core comprises an active pharmaceutical ingredient;
- the polymeric shell comprises polymeric material selected from the group consisting of polyether, polyester, polyamine, polyamide, polyurea, polyurethane, polythiocarbamate, polythiocarbonate, and polytriazole;
- the shell comprises an inner surface and an outer surface, wherein the outer surface comprises a surface functional group selected from the group consisting of—OH, —COOH, —NH2, —NHR″, and a mixture of the foregoing, wherein R″ is a C1 to C7 hydrocarbon group, wherein at least some of the surface function groups are protected by a protecting group;
- wherein the microcapsule is a controlled release microcapsule.
Dependencies are inferred from the claim text.