Cryogel scaffold capable of controlling degree of degradation and soft bio-integrated device in which drug modulating immunosuppressive action in solid microenvironment is loaded in same scaffold

A soft bio-integrated device comprising:

• a cryogel scaffold comprising a structure in which a first component and a second component are crosslinked;
• and a drug,
• wherein the first component is swollen when brought into contact with an aqueous solution, thereby increasing the volume of the scaffold,
• wherein the second component is a compound different from the first component, is crosslinkable with the first component and enables the control of degradability by an external stimulus after being crosslinked with the first component, and
• wherein the drug is a drug for controlling an immunosuppressive action in a solid tumor microenvironment, and
• wherein the first component is hyaluronic acid-methacrylate and the second component is hyaluronic acid-aldehyde methacrylate;
• or
• wherein the first component is poly(gamma-glutamic acid)) and the second component is collagen.