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US 11,590,074 B2Granted
Aerosol formulation for COPD
AssigneeChiesi Farmaceutici S.p.A.
InventorsSauro Bonelli, Francesca Usberti, Enrico Zambelli
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Abstract
Stable aerosol solution formulations comprising glycopyrronium bromide are useful for administration to patients with COPD and other respiratory conditions.
Claims17
A method for the treatment of a respiratory disorder selected from the group consisting of asthma and COPD, comprising administering to a subject in need thereof an effective amount of a pharmaceutical composition, said composition comprising glycopyrronium bromide dissolved in HFA-134a and ethanol, wherein:
- said composition comprises an amount of hydrochloric acid equivalent to 0.005 to 1.0 μg/μl of 1M hydrochloric acid;
- said composition comprises glycopyrronium bromide in an amount of 0.015 to 0.04% w/w of said composition;
- said composition comprises ethanol in an amount of 10 to 15% w/w of said composition;
- and
- said composition comprises HFA-134a in an amount of 85 to 90% w/w of said composition.
2 more elements
Dependencies are inferred from the claim text.