Methods and devices for selective disruption of fatty tissue by controlled cooling

A cooling method for selective disruption of lipid-rich cells in a non-infant human treatment subject comprising:

• applying at least one cooling element proximate to an application site of the treatment subject;
• utilizing the cooling element to decrease the temperature beneath the application site, wherein the temperature decrease is sufficient to disrupt and thereby reduce lipid-rich cells therein;
• and
• while the temperature is decreased, utilizing at least one feedback device to provide feedback information about at least one physiological parameter of the dermis or epidermis indicative of the absence of substantial crystal formation in one of the dermis or epidermis of the subject and sufficient to confirm that non-lipid-rich cells proximate to the cooling element are not disrupted, wherein the absence of substantial crystal formation is indicated by an electrical impedance of between about 10 kΩ/mm to about 50 kΩ/mm in one of the dermis or epidermis of the subject, thereby selectively disrupting lipid-rich cells in the subject.