Biodegradable, magnesium-containing bone screws, methods for their preparation and medical applications therefore

A method of remodeling tissue in a patient, comprising:

• preparing a magnesium component selected from the group consisting of magnesium and magnesium-based alloy;
• melting the magnesium component to form a melted magnesium component;
• introducing the melted magnesium component into a mold, the mold comprising;
• a cylindrical head having a top surface, a bottom planar surface, a diameter, and a thickness extending between the top surface and bottom planar surface;
• a pointed tip;
• a cylindrical shaft extending outwardly from the bottom planar surface of the cylindrical head, comprising:
• a circumference;
• a first end connected to the cylindrical head;
• a second end connected to the pointed tip;
• a length extending along a linear surface of the shaft between the first and second ends, comprising:
• a continuous non-threaded region;
• a circumferentially continuous threaded region comprising threads disposed about the circumference of the cylindrical shaft;
• and
• a transition point,
• wherein the continuous non-threaded region extends along an entirety of the length from the first end to the transition point, and the continuous threaded region extends along an entirety of the length from the transition point to the second end;
• and
• cooling and solidifying the magnesium-based alloy to have the shape of the mold.