Frequency-tunable intraluminal ultrasound device

A system for treating a target site within a body lumen of a patient comprising:

• an intraluminal ultrasound device comprising:
• a flexible elongate member configured to be positioned within a body lumen of a patient, the flexible elongate member including a distal portion and a longitudinal axis;
• and
• a transducer array disposed at the distal portion of the flexible elongate member and circumferentially positioned around the longitudinal axis of the flexible elongate member, wherein the transducer array comprises a plurality of micromachined ultrasound transducers (MUTs) arranged into a plurality of sub-arrays that are inter-connected by a plurality of flexible circuits,
• wherein a first sub-array of the transducer array is configured to obtain ultrasound imaging data of the body lumen in response to a first electrical signal applied to the MUTs in the first sub-array via the plurality of flexible circuits, and wherein a second sub-array of the transducer array is configured to apply an
• ultrasound therapy within the body lumen in response to a second electrical signal applied to the MUTs in the second sub-array via the plurality of flexible circuits, wherein the first sub-array and the second sub-array are at different positions along the longitudinal axis and comprise separate assemblies coupled together with flexible members or flexible joints;
• and
• a processing system configured to perform a method of treating the target site, the method including:
• controlling the acquisition of ultrasound imaging data using the first sub-array of the transducer array;
• determining a diameter of the body lumen and a level of calcification of the target site from the ultrasound imaging data;
• modifying the second electrical signal based on the determined diameter of the body lumen and the determined level of calcification of the target site;
• applying ultrasound therapy to the target site with the second sub-array of the transducer array operating in response to the modified second electrical signal;
• and
• repeating the controlling and determining to determine an updated diameter of the body lumen and an updated level of calcification of the target site.