System and method for task-less mapping of brain activity

A computer-implemented method of brain activity mapping in a clinical environment, the method comprising:

• providing a system comprising a computing device, the computing device comprising:
• a memory device storing a resting state network map of a subject's brain generated using resting state fMRI data collected from a brain of the subject with a task-less fMRI technique, the resting state network map comprising, for each resting state network of a plurality of resting state networks, voxels assigned to the resting state network defining the topography of the resting state network of the subject's brain, the plurality of resting state networks comprising a default mode network (DMN), a sensorimotor network (SMN), a language network (LAN), a ventral attention network (VAN), a dorsal attention network (DAN), a visual network (VIS), and a frontoparietal control network (FPC), the memory device further storing an anatomic imaging map of the subject's brain;
• and
• a processor coupled to the memory device;
• receiving, using the computing device, the resting state network map and the anatomic imaging map from the memory device;
• coregistering, using the computing device, the resting state network map with the anatomic imaging map to form a combined anatomic and functional map;
• and
• providing, using the computing device, a user output of the combined anatomic and functional map of the subject's brain;
• wherein the assignment of voxels to a resting state network is produced by transforming a plurality of correlation maps using a predetermined supervised classifier.