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US 11,584,785 B2Granted
C-peptides and proinsulin polypeptides comprising the same
AssigneeAbSci LLC
InventorsAmy Doerner, Michael Cammarata, Tyler Nusca, Suzanne A. Sprunger, Melissa Patterson
Life of this patent
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Abstract
A connecting polypeptide has SEQ ID NO:73. A proinsulin polypeptide includes a mature insulin A-chain, a mature insulin B-chain, and a connecting peptide comprising SEQ ID NO: 73 linking the mature A-chain and the mature B-chain, wherein the connecting peptide is not a native human proinsulin C-peptide. The proinsulin polypeptides according to the invention can be made in high titers and in high purity.
Claims20
A connecting polypeptide comprising SEQ ID NO:73.
A proinsulin polypeptide comprising:
- a mature insulin A-chain;
- a mature insulin B-chain;
- and
- a connecting peptide comprising SEQ ID NO:73 linking the mature A-chain and the mature B-chain, wherein the connecting peptide is not a native human proinsulin C-peptide.
1 more element
A proinsulin polypeptide comprising:
- a mature insulin A-chain comprising SEQ ID NO:6;
- a mature insulin B-chain comprising SEQ ID NO:7;
- and
- a connecting peptide comprising SEQ ID NO:
- 73 linking the mature A-chain and the mature B-chain, wherein the connecting peptide is not a native human proinsulin C-peptide.
2 more elements
A proinsulin polypeptide comprising:
- a mature insulin A-chain comprising SEQ ID NO:6;
- a mature insulin B-chain comprising SEQ ID NO:7;
- a connecting peptide comprising SEQ ID NO:73 linking the mature A-chain and the mature B-chain, wherein the connecting peptide is not a native human proinsulin C-peptide;
- and
- a carboxypeptidase B propeptide coupled to the N-terminal residue of the mature insulin B-chain, the carboxypeptidase B propeptide comprising SEQ ID NO:36.
2 more elements
Dependencies are inferred from the claim text.