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US 11,584,762 B1Granted
Near-infrared fluorescent indicators for lysosome and application thereof
AssigneeDalian University of Technology
InventorsXinfu Zhang, Yi Xiao, Xiangli Li
Life of this patent
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Abstract
The present disclosure relates to Near-infrared fluorescent indicators for lysosomes and application thereof. These indicators are composed of lipophilic NIR BODIPY derivatives and ionizable bis-tertiary amine moiety, which enable the formation of a transient amphiphilic state in acidic environments specifically. This structural feature affords accurate lysosomal membrane targeting ability at nanomole staining concentration.
Claims3
A compound of formula I:
- Wherein, R1 and R2 are each independently H, Cl, Br or I;
- R3 is H, CH3, CF3, C3H6COOCH3, C2H4COOC2H5, C2H5,
- X1 is
- X2 is H or
- Y is each independently
2 more elements
Dependencies are inferred from the claim text.