Hydantoin containing deoxyuridine triphosphatase inhibitors

A compound of formula (I):

• or a stereoisomer or a tautomer thereof, or a deuterium isotope of each of the above wherein up to 10 hydrogen atoms that are attached to one or more carbon atoms are replaced with deuterium(s), or a pharmaceutically acceptable salt of each of the foregoing, or a pharmaceutically acceptable solvate of each of the above mentioned,
• wherein
• A is
• Y1 is H or C1-C3 alkyl;
• L1 is an optionally substituted C3-C10 alkylene, wherein two geminal hydrogens together with the carbon to which they are attached are optionally replaced with cyclopropano or cyclobutano;
• L2 is —S(O)2NH—, wherein the sulfur is attached to L1 or —NHS(O)2—, wherein the nitrogen is attached to L1;
• L3 is a bond or selected from the group consisting of
• B is an optionally substituted 6-10 membered aryl.