Methods and compositions for consistent intracoronary administration of a biologic

A method for providing consistent intracoronary administration of a biologic to a plurality of subjects having diverse coronary anatomies using multiple types of guide catheters and a single type of biologic-compatible infusion catheter, the method comprising:

• (a) obtaining a plurality of kits, each kit comprising:
• (i) an infusion catheter having proximal and distal ends, wherein the infusion catheter is adapted for use in the intracoronary administration of a biologic to a subject, and wherein a contact surface of the infusion catheter comprises a material that is compatible with the biologic;
• and
• (ii) a container comprising the biologic,
• wherein the infusion catheter and biologic in each kit of the plurality of kits are materially identical;
• (b) obtaining a first guide catheter having proximal and distal ends, wherein the first guide catheter is adapted for the coronary anatomy of a first subject selected from a plurality of subjects comprising diverse coronary anatomies;
• (c) inserting the distal end of first guide catheter into a coronary artery or vein of the first subject;
• (d) advancing the infusion catheter of a first kit of the plurality of kits longitudinally within the lumen of the first guide catheter to position the distal end of the infusion catheter flush with or extending beyond the distal end of the first guide catheter;
• and
• (e) administering the biologic of the first kit of the plurality of kits to cardiac tissue of the first subject through the lumen of the infusion catheter of the first kit of the plurality of kits,
• wherein the infusion catheter of the first kit of the plurality of kits and the first guide catheter are configured such that following step (c), the infusion catheter can be moved longitudinally within the lumen of the guide catheter;
• (f) obtaining a second guide catheter having proximal and distal ends, wherein the second guide catheter is adapted for the coronary anatomy of a second subject selected from a plurality of subjects comprising diverse coronary anatomies, wherein the coronary anatomy of the second subject and second guide catheter are each different from the first guide catheter and the coronary anatomy of first subject of step (b);
• (g) inserting the distal end of second guide catheter into a coronary artery or vein of the second subject;
• (h) advancing the infusion catheter of a second kit of the plurality of kits longitudinally within the lumen of the second guide catheter to position the distal end of the infusion catheter flush with or extending beyond the distal end of the second guide catheter;
• and
• (i) administering the biologic of the second kit of the plurality of kits to cardiac tissue of the second subject through the lumen of the infusion catheter of the second kit of the plurality of kits,
• wherein the infusion catheter of the second kit of the plurality of kits and the second guide catheter are configured such that following step (g), the infusion catheter can be moved longitudinally within the lumen of the guide catheter.