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US 11,582,970 B2Granted
2-aminoimidazole-phenyl derivatives useful for controlling microbial growth
AssigneeNorth Carolina State University
InventorsChristian Melander, David Kendall Jung, Samuel Onofre Reyes
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Abstract
Provided are 2-aminoimidazole-phenyl derivative compounds of Formula (I): which compounds are useful in methods of controlling microbial growth, such as by enhancing the effects of an antibiotic administered in combination with the compound. Compositions including these compounds, devices including these compounds, and methods of using the same are also provided.
Claims49
A compound of Formula (I):
- wherein:
- R1 is selected from the group consisting of H and lower alkyl;
- R2 is selected from the group consisting of H, lower alkyl, aryl, and heteroaryl;
- R3 is selected from the group consisting of H, halo and alkoxy;
- or R2 and R3 together form a fused ring;
- and
- R4 and R5 are each independently selected from the group consisting of H, alkyl, aryl, cycloalkyl, heterocyclo, and heteroaryl,
- or a pharmaceutically acceptable salt or prodrug thereof.
5 more elements
Dependencies are inferred from the claim text.