Human bladder cancer marker AG-CD71 and antibody ABC71 and application thereof
OwnerChong Liinventor
Life of this patent
Estimating the term…
Abstract
A novel human bladder cancer marker AG-CD71 and a monoclonal antibody ABC71 for preventing AG-CD71 are provided. The human bladder cancer marker AG-CD71 is an abnormal glycosylated transferrin receptor TFRC; the abnormal glycosylated transferrin receptor TFRC refers to the TFRC carrying a saccharide structure Fucal-4(GlcNAcbl-3)[6OSO3]GlcNAc as an epitope. Also provided is an antibody for the human bladder cancer marker AG-CD71; the antibody is the monoclonal antibody ABC71 specific for the human bladder cancer AG-CD71; the monoclonal antibody is secreted from the hybridoma cell strain the preservation number of which is CGMCC No. 14312.
Claims7
An antibody for a human bladder cancer marker AG-CD71, wherein the human bladder cancer marker AG-CD71 is an abnormal glycosylated transferrin receptor, the abnormal glycosylated transferrin receptor is a transferrin receptor (TFRC) carrying a saccharide structure Fucal-4(GlcNAcbl-3)[6OSO3]GlcNAc as an epitope, an amino acid sequence of the abnormal glycosylated transferrin receptor is shown by SEQ ID No:
- 1;
- and the abnormal glycosylation is on threonine at position 104 of the abnormal glycosylated transferrin receptor;
- and the structural formula of the saccharide structure Fucal-4(GlcNAcbl-3)[6OSO3]GlcNAc is:
- the antibody specifically recognizes the saccharide structure Fucal-4(GlcNAcbl-3)[6OSO3]GlcNAc as the epitope, the antibody is a murine monoclonal antibody ABC71 specific for the human bladder cancer marker AG-CD71, and the murine monoclonal antibody ABC71 is secreted from a hybridoma cell strain with the preservation number CGMCC No. 14312.
A conjugate, wherein an antibody ABC71 for the human bladder cancer marker AG-CD71 is conjugated with a substance consisting of a component selected from the group consisting of a biomarker, an antitumor drug, a toxin, a radioactive active agent, and a magnetic particle;
- and the antibody ABC71 is a monoclonal antibody and is secreted from a hybridoma cell strain with the preservation number CGMCC No. 14312.
Dependencies are inferred from the claim text.