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US 11,578,042 B2Granted
3,5-diamino-6-chloro-N-(N-(4-(4-(2-(hexyl(2,3,4,5,6-pentahydroxyhexyl)amino)ethoxy)phenyl)butyl)carbamimidoyl)pyrazine-2-carboxamide
AssigneeParion Sciences, Inc.
InventorMichael R. Johnson
Life of this patent
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Abstract
The present invention relates to the compound of the formula: or pharmaceutically acceptable salts thereof, as well as compositions containing the same, processes for the preparation of the same, and therapeutic methods of use therefore in promoting hydration of mucosal surfaces and the treatment of diseases including chronic obstructive pulmonary disease (COPD), asthma, bronchiectasis, acute and chronic bronchitis, cystic fibrosis, emphysema, and pneumonia.
Claims42
A method of preparing a compound of Formula (I):
- or a salt thereof, the method comprising the steps of:
- (i) reacting the following compound:
- or a salt thereof, with a compound of Formula (3):
- or a salt thereof;
- and
- (ii) hydrolyzing the compound formed in step (i), or a salt thereof, in the presence of an acid, thereby forming the compound of Formula (I), or a salt thereof.
3 more elements
A method of preparing compound (Ia):
- or a salt thereof, the method comprising the steps of:
- (i) reacting the following compound:
- or a salt thereof, with the following compound:
- or a salt thereof, to form the following compound:
- or a salt thereof;
- and
- (ii) hydrolyzing compound (19), or a salt thereof, in the presence of an acid, to form compound (Ia), or a salt thereof.
4 more elements
Dependencies are inferred from the claim text.