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US 11,572,592 B2Granted
Labelling compounds and their use in assays
AssigneeBinx Health Limited
InventorsBarrie J. Marsh, Christopher G. Frost, Jonathan Sharp
Life of this patent
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Abstract
The invention provides monoferrocenyl compounds of general formula I. The invention also provides substrates labelled with the compounds, functionalised derivatives of the compounds and methods of using the compounds, functionalised derivatives and labelled substrates in electrochemical assays.
Claims8
A compound of formula III:
- wherein:
- each X substituent is independently selected from halo, vinyl, alkyl, cycloalkyl, SiR3, SnR3, PR2, P(O)R2, SR, S(O)R, SO2R, aryl, heteroaryl, CHO, CO2R, CN and CF3;
- each R is independently selected from alkyl, cycloalkyl, aryl and heteroaryl;
- Y is CH2 and Z is (CH2)3;
- [S] is a nucleic acid;
- and
- L′ is a phosphoramidite linkage to the nucleic acid,
- wherein a is 1, 2, 3 or 4 and b is 0, 1, 2, 3, 4 or 5, and
- wherein any vinyl, alkyl, cycloalkyl, alkylene, aryl and heteroaryl may optionally be substituted with 1, 2 or 3 substituents independently selected from unsubstituted alkyl, OH, CN, fluorine, chlorine, bromine and iodine.
6 more elements
Dependencies are inferred from the claim text.