Antibodies for prevention, treatment and diagnosis of P. gingivalis infection
AssigneeOral Health Australia Pty Ltd
InventorsEric Charles Reynolds, Neil Martin O'Brien Simpson, Keith J. Cross, Nada Slakeski
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Abstract
Disclosed are P. gingivalis antibodies raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein (A) the first peptide comprises a region of a P. gingivalis trypsin-like enzyme and (B) the second peptide or polypeptide comprises an adhesin domain of P. gingivalis.
Claims10
An isolated antibody raised against a chimeric or fusion protein, wherein the chimeric or fusion protein comprises a first peptide joined directly or through a linker to a second peptide or polypeptide, wherein:
- (A) said first peptide comprises a region of a Porphyromonas gingivalis trypsin-like enzyme selected from the group consisting of the amino acid sequence that is the same as, or at least 90% homologous to, the sequence shown in any one of SEQ ID NOs:
- 1-34;
- and
- (B) said second peptide or polypeptide comprises P. gingivalis adhesin domain sequence selected from the group consisting of the amino acid sequence that is the same as, or at least 90% homologous to, the sequence shown in any one of SEQ ID NOs:
- 35-39;
- Wherein the antibody is obtained by a process comprising immunizing a non-human animal with the chimeric or fusion protein, and isolating and purifying the antibody from the non-human animal.
Dependencies are inferred from the claim text.