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AssigneeThe Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.
InventorsXinle Cui, Clifford M. Snapper
Estimating the term…
Provided are antigenic compositions and uses thereof that include at least two human herpesvirus (HHV) polypeptides involved in mediating HHV binding, fusion, and entry into host cells, such as gp350, gH, gL, and gB, or nucleic acids encoding the polypeptides. The two HHV polypeptides comprise any combination of: a gB polypeptide; a gp350 polypeptide; a gL polypeptide; and a gH polypeptide, and optionally any one or more of the following polypeptides: gp42, gM, gN, gl, gC, gE, gD, ORF68, BMRF-2, BDLF2, UL128, UL130, UL131A, and gpK8.1. Also disclosed are methods of inducing an immune response or treating or preventing an HHV infection in a subject by administering to the subject at least two of the HHV polypeptides or nucleic acid(s) encoding the same. Methods of passively transferring immunity using high-titer anti-HHV antibodies or immune cells are also disclosed.
An antigenic composition comprising a combination of at least two Epstein-Barr Virus (EBV) polypeptides, the antigenic composition comprising at least a first EBV polypeptide and at least a second EBV polypeptide that are not combined to form a fusion protein, wherein:
Dependencies are inferred from the claim text.