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US 11,572,333 B2Granted
Processes for the production of isomerically pure or enriched cis-clomiphene
AssigneePcas
InventorsSergio Kreimerman, Sandrine Gauthier, Quentin Llopis
Life of this patent
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Abstract
The present disclosure relates to methods for the production of the isomerically pure or isomerically enriched cis-clomiphene and salts thereof.
Claims17
A process for the production of isomerically enriched cis-clomiphene free base or a salt thereof from isomerically pure or isomerically enriched trans-clomiphene hydrobromide comprising:
- (a) reacting hydrobromic acid with the isomerically pure or isomerically enriched trans-clomiphene hydrobromide in the absence of organic solvent to provide isomerically enriched cis-clomiphene hydrobromide, and
- (b) optionally converting the isomerically enriched cis-clomiphene hydrobromide to isomerically enriched cis-clomiphene free base or a salt thereof other than hydrobromide.
Dependencies are inferred from the claim text.