Human Streptococcus pneumoniae antibodies and uses therefor
AssigneeOklahoma Medical Research Foundation
InventorKenneth Smith
Life of this patent
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Abstract
The present invention is directed to particular monoclonal antibodies and fragments thereof that find use in the detection, prevention and treatment of Streptococcus pneumoniae infections. In particular, these antibodies may kill Streptococcus pneumoniae or limit the replication of Streptococcus pneumoniae. Also disclosed are improved methods for producing such monoclonal antibodies.
Claims21
A panel comprising two or more serotype specific antibodies or binding fragments thereof that bind to Streptococcus pneumoniae or bind to antigens of S. pneumoniae immobilized on a solid support, wherein the one or more serotype specific antibodies or binding fragments thereof comprise:
- a heavy chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth in SEQ ID NOS:
- 258 to 268, 287 to 293, 305, 325 to 330, and 355 to 359;
- and
- a light chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth SEQ ID NOS:
- 270 to 285, 306 to 312, 324, 338 to 343, and 369 to 373.
A kit for the detection of Streptococcus pneumoniae comprising a panel comprising one or more serotype specific antibodies or binding fragments thereof that bind to Streptococcus pneumoniae or bind to antigens of S. pneumoniae immobilized on a solid support, a suitable container, and an immunodetection reagent, wherein the antibodies or binding fragments thereof comprise:
- a heavy chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth in SEQ ID NOS:
- 258 to 268, 287 to 293, 305, 325 to 330, and 355 to 359;
- and
- a light chain variable domain polypeptide selected from the group consisting of the amino acid sequence set forth SEQ ID NOS:
- 270 to 285, 306 to 312, 324, 338 to 343, and 369 to 373,
- wherein the panel includes antibodies or binding fragments thereof selected to bind to S. pneumoniae serotypes 1, 2, 3, 4, 5, 6B, 8, 9N, 9V, 11B, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, 33F, and CWPS.
Dependencies are inferred from the claim text.