System and method for drug detection in exhaled breath
AssigneeSensa Bues AB
InventorsGöran Palmskog, Olof Beck
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Abstract
A portable system is disclosed for collecting a sample from exhaled breath of a subject. Drug substance in the exhaled breath are detected or determined. The sample is collected for further analysis using mass-spectroscopy. The system comprises a sampling unit and a housing arranged to hold the sampling unit, the sampling unit is adapted to collect non-volatile and volatile compounds of the at least one drug substance from the exhaled breath from the subject. The housing has at least one inlet for the subject to exhale into the housing to the sampling unit and at least one outlet for the exhaled breath to exit through.
Claims14
A portable system configured to collect a sample from exhaled breath of a subject, said system comprising:
- a sampling unit and a housing arranged to hold said sampling unit;
- said housing comprises two parts, a first part comprises an inlet and a second part comprises an outlet and said first part and said second part are configured to be connected by means of a second part being slid onto the first part of the housing;
- wherein said sampling unit having at least one filter membrane wherein said at least one filter membrane is adapted to collect at least one non-volatile compound from said exhaled breath from said subject;
- wherein said at least one filter membrane is arranged transversely across a flow path through said housing between said inlet and said outlet [configured to force] such that the exhaled breath [flowing] flows from said inlet to said outlet [to pass] through said at least one filter membrane;
- and
- wherein said inlet is configured for said subject to exhale into said housing to said sampling unit and said outlet is configured for said exhaled breath to exit through.
The system according to claim , wherein said at least one filter membrane is configured such that a pressure drop of less than 2 cm water occurs between said inlet and outlet at an exhalation flow rate of about 0-9 litre/min.
A method for portably collecting a sample from exhaled breath of a subject, and for detecting the presence or determining the quantitative amount of at least one non-volatile [component] compound in said exhaled breath, said method comprising:
- collecting [said] an exhaled breath sample comprising at least one [a] non-volatile compound from said subject, using a system comprising a sampling unit and a housing arranged to hold said sampling unit, wherein said sampling unit having at least one filter membrane wherein said at least one filter membrane is adapted to collect said at least one non-volatile compound from said exhaled breath from said subject, and said housing comprises [at least one] an inlet for said subject to exhale into said housing to said sampling unit and [at least one] an outlet for said exhaled breath to exit through;
- wherein said housing comprises a first part including said inlet and a second part including said outlet and said first part and said second part are configured to be assembled into said housing by means of said second part being slid onto the first part of the housing after said at least one filter membrane has been arranged transversely across a flow path through said housing between said inlet and said outlet, said [configured to force] exhaled breath flowing from said inlet to said outlet [to pass] through said at least one filter membrane;
- and
- analyzing said collected sample using mass-spectroscopy or Surface Enhanced Raman Spectroscopy.
Dependencies are inferred from the claim text.