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US 11,566,245 B2Granted
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
AssigneeIonis Pharmaceuticals, Inc.
InventorsSusan M. Freier, Eric E. Swayze
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Abstract
The present invention provides oligomeric compounds. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell.
Claims4
A compound comprising:
- a modified oligonucleotide having the sugar motif e-e-k-k-(D)9-e-k-e-e
- wherein each k is a bicyclic nucleoside, each e is a 2′-modified nucleoside, and each D is a 2′-deoxynucleoside;
- and
- wherein the nucleobase sequence of the modified oligonucleotide is complementary to the nucleobase sequence of a target nucleic acid.
1 more element
Dependencies are inferred from the claim text.