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US 11,566,047 B2Granted
Peptide or pharmaceutically acceptable salt thereof, or prodrug thereof
AssigneeTokyo University of Pharmacy & Life Sciences
InventorsYoshio Hayashi, Kentaro Takayama, Yoichi Negishi
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Abstract
Provided is a peptide having a short chain length, for example, having the number of amino acid residues of 20 or less and having a high myostatin inhibitory activity. The present invention is a peptide comprising an amino acid sequence represented by Formula (1) in the specification and having the number of amino acid residues of 20 or less.
Claims4
A peptide or a pharmaceutically acceptable salt of the peptide, or a prodrug thereof, the peptide
- satisfying the following (a) or (b) and having a number of amino acid residues of 20 or less:
- (a) the peptide comprising any one of the amino acid sequences represented by SEQ ID NO:
- 2 to 9, SEQ ID NO:
- 11 to 20, SEQ ID NO:
- 22 to 38, SEQ ID NO:
- 380 to 385, SEQ ID NO:
- 573 to 580, and SEQ ID NO:
- 583 to 595;
- or
- (b) the peptide comprising one amino acid sequence in which one amino acid residue of X2 to X4 and X6 to X16 in the amino acid sequences of the above (a) is substituted or deleted and having a myostatin inhibitory activity
- wherein, SEQ ID NO:
- 585 to 587 and SEQ ID NO:
- 593 to 595 may represent a cyclic peptide in which a disulfide bond is formed between side-chain SH groups of two cysteine residues.
10 more elements
Dependencies are inferred from the claim text.