Viral replication inhibitors

A method of treatment of a-Dengue virus or yellow fever virus in an animal, mammal or human, comprising administering an effective amount of a compound of formula (A), or a pharmaceutically acceptable salt thereof, optionally in combination with one or more other medicines, to an animal, mammal or human in need thereof;

• wherein,
• cycle A is phenyl;
• wherein said phenyl can be unsubstituted or substituted with one or more substituents selected from cyano and fluoro;
• cycle C is a monocycle selected from
• wherein the wavy line () indicates the point of attachment to the carbonyl of the main formula (A) and the hashed line () indicates the point of attachment to the cycle A of the main formula (A);
• X1 is selected from C;
• and N;
• X2 is selected from CR12;
• NR13;
• N;
• O;
• and S;
• X3 is selected from CR14, NR15;
• N;
• O;
• and S;
• X4 is selected from CR16, NR17;
• O;
• and S;
• each R9 is independently selected from hydrogen;
• alkyl;
• alkenyl;
• alkynyl;
• heteroalkyl;
• heteroalkenyl;
• heteroalkynyl;
• ═O;
• and ═S;
• wherein said alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• W1 is selected from CR32R32a;
• NR33;
• O;
• S;
• and SO2;
• each p and q is independently selected from 1 and 2, whereby p+q is selected from 2 and 3;
• cycle B is selected from aryl and heteroaryl;
• wherein said aryl and heteroaryl can be unsubstituted or substituted with one or more Z1a;
• R1 is aryl or
• and wherein said aryl or
• is substituted with one or two methoxy groups;
• R2 is hydrogen;
• each R12, R14, and R16 is independently selected from hydrogen;
• halogen;
• hydroxyl;
• sulfhydryl;
• trifluoromethyl;
• trifluoromethoxy;
• nitro;
• amino;
• cyano;
• alkyl;
• cycloalkyl;
• alkenyl;
• cycloalkenyl;
• alkynyl;
• cycloalkynyl;
• heteroalkyl;
• heteroalkenyl;
• and heteroalkynyl;
• wherein said alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• R13, R15, and R17 is independently selected from hydrogen;
• hydroxyl;
• sulfhydryl;
• —S(O)Z2;
• —S(O)2Z3;
• —S(O)2NZ4Z5;
• trifluoromethyl;
• —C(O)Z3;
• —C(O)OZ2;
• —C(O)NZ4Z5;
• —C(O)H;
• alkyl;
• cycloalkyl;
• alkenyl;
• cycloalkenyl;
• alkynyl;
• cycloalkynyl;
• heteroalkyl;
• heteroalkenyl;
• and heteroalkynyl;
• wherein said alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• each R32 and R32a is independently selected from hydrogen;
• halogen;
• hydroxyl;
• sulfhydryl;
• ═O;
• ═S;
• trifluoromethyl;
• trifluoromethoxy;
• cyano;
• alkyl;
• alkenyl;
• alkynyl;
• heteroalkyl;
• heteroalkenyl;
• and heteroalkynyl;
• and wherein said alkyl, alkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl, can be unsubstituted or substituted with one or more substituents selected from hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• each R33 is independently selected from hydrogen;
• alkyl;
• alkenyl;
• alkynyl;
• heteroalkyl;
• heteroalkenyl;
• and heteroalkynyl;
• and wherein said alkyl, alkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, and heteroalkynyl, can be unsubstituted or substituted with one or more substituents selected from hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• each Z1a is independently selected from the group consisting of halogen;
• —OZ2;
• and alkyl;
• wherein said alkyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —OCF3, cyano, nitro, —C(O)OH and_NH2;
• each Z2 is independently selected from alkyl;
• cycloalkyl;
• alkenyl;
• cycloalkenyl;
• alkynyl;
• cycloalkynyl;
• heteroalkyl;
• heteroalkenyl;
• heteroalkynyl;
• aryl;
• heterocycle;
• arylalkyl;
• arylalkenyl;
• arylalkynyl;
• arylheteroalkyl;
• arylheteroalkenyl;
• arylheteroalkynyl;
• heterocycle-alkyl;
• heterocycle-alkenyl;
• heterocycle-alkynyl;
• heterocycle-heteroalkyl;
• heterocycle-heteroalkenyl;
• and heterocycle-heteroalkynyl;
• wherein said alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• each Z3 is independently selected from hydroxyl;
• alkyl;
• cycloalkyl;
• alkenyl;
• cycloalkenyl;
• alkynyl;
• cycloalkynyl;
• heteroalkyl;
• heteroalkenyl;
• heteroalkynyl;
• aryl;
• heterocycle;
• arylalkyl;
• arylalkenyl;
• arylalkynyl;
• arylheteroalkyl;
• arylheteroalkenyl;
• arylheteroalkynyl;
• heterocycle-alkyl;
• heterocycle-alkenyl;
• heterocycle-alkynyl;
• heterocycle-heteroalkyl;
• heterocycle-heteroalkenyl;
• and heterocycle-heteroalkynyl;
• wherein said alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(O)OH and NH2;
• each Z4 and Z5 is independently selected from hydrogen;
• alkyl;
• cycloalkyl;
• alkenyl;
• cycloalkenyl;
• alkynyl;
• cycloalkynyl;
• heteroalkyl;
• heteroalkenyl;
• heteroalkynyl;
• aryl;
• heterocycle;
• arylalkyl;
• arylalkenyl;
• arylalkynyl;
• arylheteroalkyl;
• arylheteroalkenyl;
• arylheteroalkynyl;
• heterocycle-alkyl;
• heterocycle-alkenyl;
• heterocycle-alkynyl;
• heterocycle-heteroalkyl;
• heterocycle-heteroalkenyl;
• and heterocycle-heteroalkynyl;
• wherein said alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, aryl, heterocycle, arylalkyl, arylalkenyl, arylalkynyl, arylheteroalkyl, arylheteroalkenyl, arylheteroalkynyl, heterocycle-alkyl, heterocycle-alkenyl, heterocycle-alkynyl, heterocycle-heteroalkyl, heterocycle-heteroalkenyl, and heterocycle-heteroalkynyl can be unsubstituted or substituted with one or more substituents selected from alkyl, alkenyl, alkynyl, hydroxyl, ═O, halogen, —SH, ═S, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(O)OH or NH2;
• or wherein Z4 and Z5 can be taken together in order to form a (5-, 6-, or 7-membered) heterocycle which can be unsubstituted or substituted with alkyl, cycloalkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkynyl, hydroxyl, halogen, —SH, trifluoromethyl, —O-alkyl, —OCF3, cyano, nitro, —C(O)OH and —NH2;
• or an isomer, solvate, salt, or prodrug thereof,
• with the proviso that said compound is not
• 2-anilino-2-(4-tert-butylphenyl)-1-(2-phenyl-1-piperidyl)ethanone;
• 2-anilino-1-(2-phenyl-1-piperidyl)-2-[4-(trifluoromethyl)phenyl]ethanone;
• or
• 2-anilino-2-(4-tert-butylphenyl)-1-(2-phenylazepan-1-yl)ethenone, and
• provided that R17 is not hydrogen.