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US 11,566,012 B2Granted
Methods for treating protozoan infections
AssigneeNeoculi Pty Ltd
InventorsStephen Page, Andrew Stevens, Adam McCluskey, Martine Keenan, Rebecca Abraham
Life of this patent
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Abstract
The invention provides compounds of Formula (I), and their use in methods for treating or preventing a protozoan infection in a subject using a compound of Formula (I). The invention also provides the use of a compound of Formula (I) in the manufacture of a medicament for the treatment of a protozoan infection in a subject. The invention further provides a medical device when used in a method of treating or preventing a protozoan infection in a subject and to a medical device comprising the composition of the invention.
Claims17
A compound chosen from the following:
- NCL238
- 4,6-bis(2-((E)-(6-chloropyridin-3-
- yl)methylene)hydrazinyl)pyrimidin-2-amine
- NCL239
- 4,6-bis(2-((E)-pyridin-3-ylmethylene)hydrazinyl)pyrimidin-2-
- amine
- NCL240
- 4,6-bis(2-((E)-pyridin-2-ylmethylene)hydrazinyl)pyrimidin-2-
- amine
- NCL241
- 4,6-bis(2-((E)-pyridin-4-ylmethylene)hydrazinyl)pyrimidin-2-
- amine
- NCL242
- 4,6-bis(2-((E)-2,5-dihydroxybenzylidene)hydra-
- zinyl)pyrimidin-2-aminium 2-formyl-4-hydroxyphenolate
- NCL243
- 4,6-bis(2-((E)-3,4-dihydroxybenzylidene)hydra-
- zinyl)pyrimidin-2-amine
- NCL244
- 4,6-bis(2-((E)-2,3-dihydroxybenzylidene)hydra-
- zinyl)pyrimidin-2-aminium 2-formyl-6-hydroxyphenolate
- NCL245
- 4,6-bis(2-((E)-naphthalen-1-ylmethylene)hydra-
- zinyl)pyrimidin-2-amine
- NCL246
- 4,6-bis(2-((1E,2E)-3-phenylallylidene)hydrazinyl)pyrimidin-
- 2-amine
- NCL247
- 4,6-bis(2-((E)-3,4,5-trihydroxybenzylidene)hydra-
- zinyl)pyrimidin-2-amine
- NCL255
- 4,6-bis(24(E)-[1,1'-biphenyl]-4-ylmethylene)hydra-
- zinyl)pyrimidin-2-amine
- NCL256
- 4,6-bis(2-((E)-2,4-dihydroxybenzylidene)hydra-
- zinyl)pyrimidin-2-amine
- NCL262
- 4,6-bis(2-((E)-3-phenylpropylidene)hydrazinyl)pyrimidin-2-
- amine
- NCL264
- 4,6-bis(2-((E)-naphthalen-2-ylmethylene)hydra-
- zinyl)pyrimidin-2-amine
- or a stereoisomer, tautomer, pharmaceutically acceptable salt thereof.
40 more elements
Dependencies are inferred from the claim text.