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US 11,565,996 B2Granted
Compounds for use as inhibitors of alternative oxidase or cytochrome bc1 complex
AssigneeAlternOx Scientific Limited
InventorsAnthony Lennox Moore, Mary Susan Albury, Luke Edward Young, Catherine Elliott
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Abstract
The invention provides compounds for use in inhibiting a microbial alternative oxidase (AOX) and/or cytochrome bc1 complex. The invention extends to the use of such inhibitors in agrochemicals and in pharmaceuticals, for treating microbial infections, including fungal infections.
Claims13
A method of treating a fungal infection in a subject, the method comprising administering to a subject in need of such treatment a therapeutically effective amount of the compound of formula I:
- wherein R1 is a group selected from:
- CHO;
- CN;
- C(O)NH2;
- C(O)NHCH3;
- C(O)CH3;
- COOH;
- and COOCH3;
- R2 is hydrogen, hydroxyl or an alkoxy group with 1 to 3 C atoms;
- R3 is a straight chain or branched alkyl or alkylene with 4 to 20 C atoms, that is optionally mono- or polysubstituted by a C1 to C4 alkyl group;
- R4 is a hydroxyl group;
- R5 is a halogen group;
- and
- R6 is H or a C1 to C4 alkyl group,
- wherein the fungal infection is caused by a fungus comprising an alternative oxidase (AOX).
12 more elements
Dependencies are inferred from the claim text.