Inhibitors of histone lysine specific demethylase (LSD1) and histone deacetylases (HDACS)

A compound of Formula (IIb):

• wherein:
• t is an integer selected from the group consisting of 0, 1, 2, 3, and 4;
• A is substituted or unsubstituted aryl;
• B is aryl;
• L is —[X1—C(═O)—NR1]d—, wherein d is 1;
• wherein X1 is —(CH2)n—, wherein n is 3, wherein the —(CH2)n— group can optionally be substituted with a substituent selected from the group consisting of substituted or unsubstituted linear or branched alkyl, hydroxyl, alkoxyl, amino, cyano, halogen, and oxo, and wherein one or more carbon atoms of —(CH2)n— can optionally be replaced with one or more heteroatoms selected from the group consisting of O, S, and NR′1, wherein each —(CH2)n— group can contain a cycloalkyl or cycloheteroalkyl unit;
• L2 is selected from the group consisting of aryl, heteroaryl, —(CH2)n—, —(CH2)n—CH═CH—(CH2)m—, —(CH2)n—C≡C—(CH2)m—,—(CH2)m—O—, wherein n and m are each independently an integer selected from the group consisting of 0, 1, 2, 3, 4, 5, and 6, wherein the —(CH2)n—, —(CH2)m—, and —CH═CH— groups can optionally be substituted with a substituent selected from the group consisting of substituted or unsubstituted linear or branched alkyl, hydroxyl, alkoxyl, amino, cyano, halogen, and oxo, and wherein one or more carbon atoms of —(CH2)n— and —(CH2)m— can optionally be replaced with one or more heteroatoms selected from the group consisting of 0, S, and NR′1;
• R1 and R′1 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted linear or branched alkyl, alkoxyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl, and R1 can form a ring system with ring B via a substituted or unsubstituted alkylene or heteroalkylene chain;
• R2 is selected from the group consisting of —(CH2)p—NR3—NR4R5, —(CH2)p—X2, and —NH2;
• wherein p is an integer selected from the group consisting of 0, 1, 2, 3, and 4, and wherein the —(CH2)p— group can be saturated or unsaturated or contain a cycloalkyl unit and optionally be substituted with a substituent selected from the group consisting of substituted or unsubstituted linear or branched alkyl, hydroxyl, alkoxyl, amino, cyano, halogen, and oxo, and one or more carbon atoms of —(CH2)p— can optionally be replaced with one or more heteroatoms selected from the group consisting of 0, S, and NR′1;
• each R′2 is independently selected at each occurrence from the group consisting of substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, allyl, hydroxyl, alkoxyl, amino, cyano, carboxyl, halogen, nitro, oxo, —CF3, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl;
• R3, R4, and R5 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted linear or branched alkyl, alkoxyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl, and —C(═O)—O—R21, or R4 and R5 together can form a substituted or unsubstituted 4- to 6-membered cycloalkyl, and wherein R24 is substituted or unsubstituted linear or branched alkyl;
• X2 is selected from the group consisting of hydroxyl, halogen, and —O—Si(R21R22)2-R23, wherein R21, R22, and R23 are each independently substituted or unsubstituted linear or branched alkyl;
• Y is selected from the group consisting of null, —N(R10)C(═O)—,—C(═O)N(R10)—, —N(R10)C(═S)—, —C(═S)N(R10—, —SO2—, —N(R10) SO2—, —N(R10SO2N(R10)—, —SO2N(R10)—, and —CH═CH—;
• Z is selected from the group consisting of:
• —C(═O)N(R10)OH, —C(═O)OR16, N(R10)OH, —N(R10)C(═O)C(R11)n′S(R12),
• —B(OR13)m′, —SR14,
• wherein R10, R11, R12, R13, R14, and R15 are each independently selected from the group consisting of hydrogen, substituted or unsubstituted linear or branched alkyl, alkoxyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloheteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, substituted or unsubstituted arylalkyl, and substituted or unsubstituted heteroarylalkyl;
• R16, R17, R18, and R19 are each independently substituted or unsubstituted linear or branched alkyl;
• and n′ and m′ are integers each independently selected from the group consisting of 0, 1, and 2;
• or pharmaceutically acceptable salts, hydrates, and solvates thereof.