US 11,564,970 B2Granted

Compositions and methods for combinatorial drug discovery in nanoliter droplets

AssigneesThe Broad Institute, Inc., Massachusetts Institute of Technology

InventorsPaul Blainey, Anthony Kulesa, Jared Kehe

Life of this patent

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Abstract

Compositions and methods for combinatorial drug discovery in nanoliter droplets are described. Novel synergistic agents that increase efficacy of antibiotic agents to treat bacterial infection are disclosed.

Claims7

Dependent claims

A composition comprising an antibiotic selected from the group consisting of vancomycin, cycloserine, fosfomycin, novobiocin, erythromycin, tetracycline, ampicillin, trimethoprim, chloramphenicol, and norflaxacin, and combinations thereof and Iodophenpropit.

Dependencies are inferred from the claim text.

Facts

Application: 16/754,668Filed 9 Oct 2018 · us provisional application
Priority: 9 Oct 2017
Published: US 2020/0353033 A112 Nov 2020
Granted: 31 Jan 2023
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

A61K 38/12
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: cyclic peptides , e.g. bacitracins; Polymyxins; Gramicidins…
A61K 31/132
Amines: having two or more amino groups, e.g. spermidine, putrescine
A61K 31/14
Amines: quaternary ammonium compounds, e.g. edrophonium, choline
A61K 31/165
Amides, e.g. hydroxamic acids: having aromatic rings, e.g. colchicine, atenolol, progabide

Family

Application62/570,014Us provisional application · filed 9 Oct 2017
Application62/570,585Us provisional application · filed 10 Oct 2017
Application62/578,140Us provisional application · filed 27 Oct 2017
US 2020/0353033 A1Pre-grant publication · published 12 Nov 2020
US 11,564,970 B2This patent

From the US filing history. Foreign family members aren’t listed.

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