Aggregating microparticles for medical therapy
AssigneeGraybug Vision, Inc.
InventorsYun Yu, Joshua Kays, Ming Yang, Jeffrey L. Cleland
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Abstract
The present invention is a surface treated drug-loaded solid (e.g., non-porous) microparticle that aggregates in vivo to form a consolidated larger particle for medical therapy. In one embodiment, the particles are used for ocular therapy. Processes for producing the surface treated microparticle and injectable formulations which include the surface treated microparticle are also provided. When used in the eye, long-term consistent intraocular delivery can be achieved without disrupting vision and minimizing undesirable inflammatory responses.
Claims59
Surface-modified aggregating microparticles comprising at least one biodegradable polymer, a surfactant, and a therapeutic agent that is not covalently bound to the biodegradable polymer wherein the microparticles have a mean diameter between 10 μm and 60 μm that:
- (i) contain from about 0.001 percent to about 1 percent surfactant and have been surface-modified to contain less surfactant than a microparticle prior to the surface modification wherein the surface has been modified at a temperature less than about 18° C.;
- and
- (ii) aggregate in vivo to form at least one pellet of at least 500 μm in vivo capable of sustained drug delivery in vivo for at least one month.
Dependencies are inferred from the claim text.