Sterile lyophilized drug compositions and methods for treating ocular diseases or conditions

A sterile lyophilized drug composition comprising:

• i) particles of biodegradable polymer and a drug, wherein the drug comprises 0.5 wt % to 70.0 wt % of the weight of the particles, wherein the particles have a mean diameter of 1 micron to 100 microns;
• ii) a soluble, biodegradable or bioerodible excipient present in an amount from 0.3 wt % to 90.0 wt %, wherein the excipient is a viscoelastic polymer selected from the group consisting of high molecular weight polyvinylpyrrolidone, polyethylene glycol, polyethylene oxide and polymeric lipids, hyaluronic acid, and chondroitin sulfate, or combinations thereof;
• and
• iii) a bulking agent present in an amount from 5.0 wt % to 50.0 wt %, wherein the bulking agent is for reconstitution of the lyophilized drug composition.