Compounds inhibiting Nef-calnexin interaction
AssigneeThe George Washington University
InventorsAlexei Adzhubei, Michael Bukrinsky, Ruth Hunegnaw
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Abstract
The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.
Claims9
A small molecule having the structure of Formula (III):
- wherein:
- R is H, CH2OH, COOH or COOCH3;
- and
- X is CH2, NH, O, NCH3, or SO2.
A method for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) comprising delivering to the cell an effective amount of a composition or formulation comprising a small molecule of Formula (III) or an analog or derivative thereof:
- wherein:
- R, R1, and R2 are independently selected from H, CH2OH, COOH or COOCH3;
- and
- X is CH2, NH, O, NCH3, or SO2.
A method for treating or preventing atherosclerosis in a subject infected with HIV comprising administering to said subject an effective amount of a composition or formulation comprising a small molecule of Formula (III):
- wherein:
- R is H, CH2OH, COOH or COOCH3;
- and
- X is CH2, NH, O, NCH3, or SO2;
- and
- wherein the small molecule prevents or decreases an interaction between a Nef protein and a Calnexin protein.
Dependencies are inferred from the claim text.