Aptamers for targeting HPV16-positive tumor cells
OwnerAida Gholoobi, Zahra Meshkat +2inventors
InventorsAida Gholoobi, Zahra Meshkat, Khalil Abnous, Majid Ghayour Mobarhan
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Abstract
A composition for binding to human papillomavirus type 16 (HPV16)-positive tumor cells, the composition including a DNA aptamer. The DNA aptamer includes one of SEQ ID NO: 1 and SEQ ID NO: 2.
Claims20
A composition for binding to human papillomavirus type 16 (HPV16)-positive tumor cells, the composition comprising a DNA aptamer, the DNA aptamer comprising one of SEQ ID NO:
- 1 and SEQ ID NO:
- 2.
A method for detecting human papillomavirus type 16 (HPV16)-positive tumor cells in a biological sample, the method comprising:
- putting the biological sample in contact with a composition, the composition comprising:
- a DNA aptamer comprising one of SEQ ID NO:
- 1 and SEQ ID NO:
- 2;
- and
- a diagnostic tag conjugated to the DNA aptamer;
- and
- determining the presence of an HPV16-positive tumor cell in the biological sample responsive to detecting the DNA aptamer bound to the HPV16-positive tumor cell.
A method for targeting human papillomavirus type 16 (HPV16)-positive tumor cells in a subject, the method comprising administering a composition to the subject, the composition comprising:
- a DNA aptamer comprising one of SEQ ID NO:
- 1 and SEQ ID NO:
- 2;
- and
- a tag conjugated to the DNA aptamer, the tag comprising at least one of a diagnostic tag and a therapeutic tag.
Dependencies are inferred from the claim text.