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US 11,560,556 B2Granted
Protein C-factor VII chimeras
AssigneesDuke University, The U.S. Government represented by the Department of Veteran Affairs
InventorsAmmon Fager, Maureane Hoffman
Life of this patent
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Abstract
Provided are chimeric Protein C-Factor VII proteins comprising a Gla domain from Protein C (PC), an EGF-1 domain from PC, an EGF-2 domain from Factor VII (FVII), and a protease domain from FVII.
Claims12
A chimeric Protein C-Factor VII (PC-FVII) protein comprising a Gla domain of Protein C (PC), an EGF-1 domain of PC, an EGF-2 domain of Factor VII (FVII), and a protease domain of FVII,
- wherein the chimeric PC-FVII protein comprises the amino acid sequence of SEQ ID NO:
- 6 and
- activates Factor X.
Dependencies are inferred from the claim text.