Resveratrol-piperazine co-crystals

A method for producing a resveratrol-piperazine co-crystal, Form 1, characterized by having an XRPD pattern comprising peaks at 4.48, 13.32, 16.96, 18.88, 19.16, and 22.84 °28±0.2 °28, or Form 2, characterized by having an XRPD pattern comprising peaks at 5.87, 12.74, 17.43, 17.70, 20.55, and 21.32 °28±0.2 °28, said method comprising the steps of:

• a) grinding a mixture comprising resveratrol, piperazine and a solvent selected from ethanol or tetrahydrofuran;
• b) allowing the mixture of step a) to dry thereby providing a further mixture comprising Form 1 when the solvent is ethanol in step a) or Form 2 when the solvent is tetrahydrofuran in step a);
• and
• c) optionally subjecting the further mixture to further grinding.