CA IX-NIR dyes and their uses
AssigneeOn Target Laboratories, LLC
InventorsSumith A. Kularatne, Mini Thomas
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Abstract
The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
Claims20
A method of imaging cancer or inflammatory diseases, the method comprising contracting tissue with a compound, or salt thereof, the compound having the formula:
- B-W-X-Y-Z
- wherein B is a CA IX-targeted molecule is selected from the group consisting of
- wherein n is 0, 1, 2, or 3;
- m is 0, 1, 2, 3, 4, or 5, and p is 0, 1, 2, or 3;
- W comprises an extended hydrophobic residue;
- X comprises a hydrophobic spacer;
- Y comprises an amino acid spacer;
- and
- Z comprises a NIR dye,
- illuminating the tissue with an excitation light of a wavelength absorbed by the compound;
- and
- detecting the optical signal emitted by the compound in the tissue.
A composition comprising a compound selected from the group consisting of:
- and at least one additional fluorescent compound.
Dependencies are inferred from the claim text.