Determining intrinsic viscosity and Huggins constant of an unknown sample

A system comprising:

• a memory;
• and
• a processor in communication with the memory, the processor configured to perform a method comprising
• receiving concentration detector signal values over time, cmeas(t), from a concentration detector,
• wherein the concentration detector signal values correspond to concentration values of a series of aliquots of an unknown sample injected into an instrument chain,
• wherein the instrument chain comprises the concentration detector,
• receiving specific viscosity values over time, ηsp(t), from a viscometer,
• wherein the specific viscosity values correspond to the series of aliquots,
• wherein the instrument chain further comprises the viscometer,
• executing a set of logical operations calculating a total mass of each of the aliquots, mi, as a first integral function of the received concentration detector signal values, cmeas(t), corresponding to the each of the aliquots,
• executing a set of logical operations calculating a first intermediate viscosity value of the each of the aliquots, Iηi, as a second integral function of the received specific viscosity values, ηsp(t), corresponding to the each of the aliquots,
• executing a set of logical operations calculating a second intermediate viscosity value of the each of the aliquots, I2ηi, as a third integral function of the received specific viscosity values, ηsp(t), corresponding to the each of the aliquots, and
• executing a set of logical operations fitting the total mass of the each of the aliquots, mi, the first intermediate viscosity value of the each of the aliquots, Iηi, and the second intermediate viscosity value of the each of the aliquots, I2ηi, to a fitting function comprising the first integral function, a floating intrinsic viscosity of the unknown sample, [η], the second integral function, a floating Huggins constant of the unknown sample, Kh, and the third integral function, resulting in a calculated intrinsic viscosity of the unknown sample and a calculated Huggins constant of the unknown sample.

A non-transitory computer program product comprising a computer readable storage medium having program instructions embodied therewith, the program instructions executable by a processor to cause the processor to perform a method comprising:

• receiving concentration detector signal values over time, cmeas(t), from a concentration detector,
• wherein the concentration detector signal values correspond to concentration values of a series of aliquots of an unknown sample injected into an instrument chain,
• wherein the instrument chain comprises the concentration detector;
• receiving specific viscosity values over time, ηsp(t), from a viscometer,
• wherein the specific viscosity values correspond to the series of aliquots,
• wherein the instrument chain further comprises the viscometer;
• executing a set of logical operations calculating a total mass of each of the aliquots, mi, as a first integral function of the received concentration detector signal values, cmeas(t), corresponding to the each of the aliquots;
• executing a set of logical operations calculating a first intermediate viscosity value of the each of the aliquots, Iηi, as a second integral function of the received specific viscosity values, ηsp(t), corresponding to the each of the aliquots;
• executing a set of logical operations calculating a second intermediate viscosity value of the each of the aliquots, I2ηi, as a third integral function of the received specific viscosity values, ηsp(t), corresponding to the each of the aliquots;
• and
• executing a set of logical operations fitting the total mass of the each of the aliquots, mi, the first intermediate viscosity value of the each of the aliquots, Iηi, and the second intermediate viscosity value of the each of the aliquots, I2ηi, to a fitting function comprising the first integral function, a floating intrinsic viscosity of the unknown sample, [η], the second integral function, a floating Huggins constant of the unknown sample, Kh, and the third integral function, resulting in a calculated intrinsic viscosity of the unknown sample and a calculated Huggins constant of the unknown sample.