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US 11,555,204 B2Granted
Promoter of Hspa5 gene
AssigneeDaiichi Sankyo Company, Limited
InventorsKenji Masuda, Koichi Nonaka, Hiroki Tanemura
Life of this patent
Estimating the term…
Abstract
The present invention provides an approach to enhancing the production of a foreign protein serving as a protein-based pharmaceutical product in host cells such as cultured cells derived from a mammal. The present invention provides transformed cells having a novel Hspa5 gene promoter, and a method for secreting and producing a foreign protein at high levels using the transformed host cells.
Claims20
A polynucleotide consisting of a nucleotide sequence selected from (a) to (f):
- (a) a polynucleotide consisting of the nucleotide sequence of SEQ ID NO:
- 1;
- (b) a polynucleotide consisting of nucleotides 444 to 2949 of SEQ ID NO:
- 1 as set forth in the nucleotide sequence of SEQ ID NO:
- 5;
- (c) a polynucleotide consisting of nucleotides 944 to 2949 of SEQ ID NO:
- 1 as set forth in the nucleotide sequence of SEQ ID NO:
- 6;
- (d) a polynucleotide consisting of nucleotides 1443 to 2949 of SEQ ID NO:
- 1 as set forth in the nucleotide sequence of SEQ ID NO:
- 7;
- (e) a polynucleotide consisting of nucleotides 1841 to 2949 of SEQ ID NO:
- 1 as set forth in the nucleotide sequence of SEQ ID NO:
- 8;
- and
- (f) a polynucleotide consisting of nucleotides 2341 to 2949 of SEQ ID NO:
- 1 as set forth in the nucleotide sequence of SEQ ID NO:
- 9.
15 more elements
Dependencies are inferred from the claim text.